Prevalence of hypovitaminosis D in women of reproductive age from Colombian coffee region. Cross-sectional study.
Abstract
Objective: to determine the prevalence of hypovitaminosis D in women of reproductive age, in the Coffee Region, Colombia.
Materials and methods: cross-sectional study, in a diverse population of 246 women who attended gynecological care for sterility / infertility, in three highly complex clinics in the Coffee Region (Armenia, Pereira and Manizales), Colombia; between 2016 and 2020. Vitamin D was measured through the plasma concentration of 25-hydroxyvitamin D3 ([25 (OH) D3]), which was determined using ARCHITECT 25-OH Vitamin D (automated immunoassay). The global prevalence of vitamin D deficiency was estimated, and both insufficiency and deficiency were evaluated. Descriptive statistics were applied.
Results: the mean age of the participants was 29.75 ± 4.63 years. In the global population, the mean concentration of [25 (OH) D3] was 34.68 ± 13.65 ng / mL. The prevalence of hypovitaminosis D in the total population was 38.61% (n = 95/246); the insufficiency being 64.21% (n = 61/95) (values less than 30 ng / mL), and the deficiency of 35.78% (n = 34/95) (values less than 20 ng / ml). 12.18% of fertility problems were observed.
Conclusions: hypovitaminosis D, in women of reproductive age from the Coffee Region, was present in more than 1/3 of the participating population; the insufficiency prevailing in 2/3 of the women. Knowledge of the prevalence of vitamin D deficiency among women of reproductive age could promote treatment and prevention strategies.
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GinecologyReferences
Rojas-Rivera J, De La Piedra C, Ramos A, Ortiz A, Egido J. The expanding spectrum of biological actions of vitamin D. Nephrol Dial Transplant. 2010; 25(9):2850-65. https://doi.org/10.1093/ndt/gfq313
Cesari M, Incalzi RA, Zamboni V, Pahor M. Vitamin D hormone: a multitude of actions potentially influencing the physical function decline in older persons. Geriatr Gerontol Int. 2011; 11(2):133-42. https://doi.org/10.1111/j.1447-0594.2010.00668.x
Espitia De La Hoz FJ, Orozco Santiago L. Prevalencia del déficit de vitamina D y de los factores de riesgo asociados, en gestantes del Quindío. Revista Colombiana de Endocrinología, Diabetes & Metabolismo. 2018; 5(4):5-12.
Stachowicz M, Lebiedzińska A. The role of vitamin D in health preservation and exertional capacity of athletes. Postepy Hig Med Dosw (Online). 2016; 70(0):637-43. https://doi.org/10.5604/17322693.1205363
Khammissa RAG, Fourie J, Motswaledi MH, Ballyram R, Lemmer J, Feller L. The Biological Activities of Vitamin D and Its Receptor in Relation to Calcium and Bone Homeostasis, Cancer, Immune and Cardiovascular Systems, Skin Biology, and Oral Health. Biomed Res Int. 2018; 2018:9276380. https://doi.org/10.1155/2018/9276380
Espitia De La Hoz. Déficit de vitamina D en hombres y mujeres con deseo sexual hipoactivo: Estudio de prevalencia. Rev. Méd. Risaralda 2020; 26(2):123-9. https://doi.org/10.22517/25395203.23251
Wacker M, Holick MF. Sunlight and Vitamin D: A global perspective for health. Dermatoendocrinol. 2013; 5(1):51-108. https://doi.org/10.4161/derm.24494
Heaney RP. Vitamin D in health and disease. Clin J Am Soc Nephrol. 2008; 3(5):1535-41. https://doi.org/10.2215/CJN.01160308
Holick MF. High prevalence of vitamin D inadequacy and implications for health. Mayo Clin Proc. 2006; 81(3):353-73. https://doi.org/10.4065/81.3.353
Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014; 144 Pt A:138-45. DOI: https://doi.org/10.1016/j.jsbmb.2013.11.003
Espitia De La Hoz FJ, Orozco Santiago L. Prevalencia del déficit de vitamina D en mujeres posmenopáusicas de Armenia. Revista Colombiana de Endocrinología, Diabetes & Metabolismo. 2019; 6(3):171-6.
Avci E, Demir S, Aslan D, Nar R, Şenol H. Assessment of Abbott Architect 25-OH vitamin D assay in different levels of vitamin D. J Med Biochem. 2020; 39(1):100-107. https://doi.org/10.2478/jomb-2019-0039
Hutchinson K, Healy M, Crowley V, Louw M, Rochev Y. Verification of Abbott 25-OH-vitamin D assay on the architect system. Pract Lab Med. 2017; 7:27-35. https://doi.org/10.1016/j.plabm.2017.01.001
Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G, Ragi-Eis S, Chandler J. The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Intern Med. 2006; 260(3):245-54. https://doi.org/10.1111/j.1365-2796.2006.01685.x
Martínez-Sánchez LM, Gallego-González D, Gómez-Otálvaro MA, Rodríguez-Gázquez MA, Hormaza-Ángel MP. Concentraciones de 25-hidroxivitamina-D en mujeres que asisten a una consulta externa privada en Medellín, Colombia. Ginecol Obstet Mex. 2018; 86(1):89-95. https://doi.org/10.24245/gom.v86i2.1449.
Rizzoli R. Vitamin D supplementation: upper limit for safety revisited?. Aging Clin Exp Res. 2021; 33(1): 19-24. https://doi.org/10.1007/s40520-020-01678-x
Hicks GE, Shardell M, Miller RR, Bandinelli S, Guralnik J, Cherubini A, Lauretani F, Ferrucci L. Associations between vitamin D status and pain in older adults: the Invecchiare in Chianti study. J Am Geriatr Soc. 2008; 56(5):785-91. https://doi.org/10.1111/j.1532-5415.2008.01644.x
Kerley CP, Elnazir B, Faul J, Cormican L. Vitamin D as an adjunctive therapy in asthma. Part 1: A review of potential mechanisms. Pulm Pharmacol Ther. 2015; 32: 60-74. https://doi.org/10.1016/j.pupt.2015.02.004
Pilz S, Tomaschitz A, Ritz E, Pieber TR. Vitamin D status and arterial hypertension: a systematic review. Nat Rev Cardiol. 2009; 6(10): 621-630. https://doi.org/10.1038/nrcardio.2009.135
Płudowski P, Karczmarewicz E, Bayer M, Carter G, Chlebna-Sokół D, Czech-Kowalska J, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe-recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013; 64(4):319-27. DOI: https://doi.org/10.5603/ep.2013.0012
Viganò P, Lattuada D, Mangioni S, Ermellino L, Vignali M, Caporizzo E, et al. Cycling and early pregnant endometrium as a site of regulated expression of the vitamin D system. J Mol Endocrinol. 2006; 36(3): 415-24. https://doi.org/10.1677/jme.1.01946
Kinuta K, Tanaka H, Moriwake T, Aya K, Kato S, Seino Y. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinology. 2000; 141(4):1317-1324. DOI: https://doi.org/10.1210/endo.141.4.7403
Hurley WL, Doane RM. Recent developments in the roles of vitamins and minerals in reproduction. J Dairy Sci. 1989; 72(3):784-804. DOI: https://doi.org/10.3168/jds.S0022-0302(89)79170-0
Hormaza MP, Cuesta D, Martínez LM, Massaro MM, Campo MN, Vélez MP, et al. Niveles séricos de 25 hidroxivitamina D en mujeres no menopáusicas, menopáusicas y posmenopáusicas. Rev Colomb Obstet Ginecol. 2011; 62(3):231-6.
Al-Alyani H, Al-Turki HA, Al-Essa ON, Alani FM, Sadat-Ali M. Vitamin D deficiency in Saudi Arabians: A reality or simply hype: A meta-analysis (2008-2015). J Family Community Med. 2018; 25(1):1-4. DOI: https://doi.org/10.4103/jfcm.JFCM_73_17
Ginde AA, Liu MC, Camargo CA Jr. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med. 2009; 169(6):626-32. https://doi.org/10.1001/archinternmed.2008.604
Moy FM, Hoe VC, Hairi NN, Vethakkan SR, Bulgiba A. Vitamin D deficiency and depression among women from an urban community in a tropical country. Public Health Nutr. 2017; 20(10): 1844-1850. https://doi.org/10.1017/S1368980016000811
Aydogmus H, Demirdal US. Vitamin D Deficiency and Lower Urinary Tract Symptoms in Women. Eur J Obstet Gynecol Reprod Biol. 2018; 228:48-52. https://doi.org/10.1016/j.ejogrb.2018.06.009
Triggianese P, Watad A, Cedola F, Perricone C, Amital H, Giambini I, Perricone R, Shoenfeld Y, De Carolis C. Vitamin D deficiency in an Italian cohort of infertile women. Am J Reprod Immunol. 2017; 78(4). https://doi.org/10.1111/aji.12733
Smith LM, Gallagher JC. Effect of vitamin D supplementation on total and free 25 hydroxyvitamin D and parathyroid hormone. An analysis of two randomized controlled trials. J Intern Med. 2019; 286(6):651-659. DOI: https://doi.org/10.1111/joim.12950
Zhao J, Liu S, Wang Y, Wang P, Qu D, Liu M, Ma W, Li Y.Vitamin D improves in-vitro fertilization outcomes in infertile women with polycystic ovary syndrome and insulin resistance. Minerva Med. 2019; 110(3): 199-208. https://doi.org/10.23736/S0026-4806.18.05946-3
Ozkan S, Jindal S, Greenseid K, Shu J, Zeitlian G, Hickmon C, Pal L. Replete vitamin D stores predict reproductive success following in vitro fertilization. Fertil Steril. 2010; 94(4): 1314-9. https://doi.org/10.1016/j.fertnstert.2009.05.019
Nair R, Maseeh A. Vitamin D: The "sunshine" vitamin. J Pharmacol Pharmacother. 2012; 3(2): 118-126. https://doi.org/10.4103/0976-500X.95506
Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007; 167(16):1730-7. https://doi.org/10.1001/archinte.167.16.1730
Alavi N, Ebrahimi M, Akbari-Asbagh F. The effect of vitamin D status on ovarian reserve markers in infertile women: A prospective cross-sectional study. Int J Reprod Biomed. 2020; 18(2):85-92. https://doi.org/10.18502/ijrm.v18i2.6501
Lata I, Tiwari S, Gupta A, Yadav S, Yadav S. To Study the Vitamin D Levels in Infertile Females and Correlation of Vitamin D Deficiency with AMH Levels in Comparison to Fertile Females. J Hum Reprod Sci. 2017; 10(2):86-90. https://doi.org/10.4103/jhrs.JHRS_105_16
Merhi Z, Doswell A, Krebs K, Cipolla M. Vitamin D alters genes involved in follicular development and steroidogenesis in human cumulus granulosa cells. J Clin Endocrinol Metab. 2014; 99(6): E1137-45. https://doi.org/10.1210/jc.2013-4161
Rudick BJ, Ingles SA, Chung K, Stanczyk FZ, Paulson RJ, Bendikson KA. Influence of vitamin D levels on in vitro fertilization outcomes in donor-recipient cycles. Fertil Steril. 2014; 101(2): 447-52. https://doi.org/10.1016/j.fertnstert.2013.10.008
Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005; 10(2): 94-111.
Kho AT, Bhattacharya S, Tantisira KG, et al. Transcriptomic analysis of human lung development. Am J Respir Crit Care Med. 2010; 181(1): 54-63. https://doi.org/10.1164/rccm.200907-1063OC
Wyness SP, Straseski JA. Performance characteristics of six automated 25-hydroxyvitamin D assays: Mind your 3s and 2s. Clin Biochem. 2015; 48(16-17): 1089-96. https://doi.org/10.1016/j.clinbiochem.2015
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