Atopic dermatitis in siblings patients: case report and considerations on consanguinity in atopic dermatitis
Abstract
Aim: In this case report, the difference in clinical presentation of atopic dermatitis in two sisters is discussed. We do a brief review of the literature regarding the existing association between siblings and the factors that can influence the characteristics and evolution of the disease.
Case report: A case of atopic dermatitis occurs in two sisters who debut with a similar disease severity but slightly greater and with a different evolution in the younger sister, who did not present an improvement with the initial therapeutic regimen and needed to extend paraclinical tests. An allergic component to metals is observed and it is decided to escalate towards a biological treatment (Dupilumab).
Conclusions: Atopic dermatitis is a disease with heterogeneous clinical and paraclinical manifestations in which multiple intrinsic and extrinsic pathophysiological mechanisms converge. The association between genetic predisposition, heredity, microbiome, and other factors possibly involved in the appearance of atopic dermatitis among affected siblings has not been defined yet. Therefore, it is recommended to carry out studies that assess the importance of this factor and associated variables.
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Disciplines:
Dermatology, Public HealthReferences
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