Meningeal carcinomatosis. Case report

  • Tomas Omar Zamora Bastidas Universidad del Cauca
  • Harold Jofre Bolaños Bravo Universidad del Cauca
  • Manuel Felipe Cáceres Acosta Universidad del Cauca
  • Stephany Arias Linthon Universidad del Cauca
Keywords: Meningeal carcinomatosis, Cerebrospinal Fluid (CSF), Stomach Neoplasms, Eye Neoplasms, Case report

Abstract

We present the case of a 66-year-old male patient, hypertensive, with diffuse gastric adenocarcinoma stage IV and malignant tumor of right orbit. The patient consulted for loss of consciousness and incoherent language. Physical examination revealed meningeal signs. Lumbar puncture showed elevated opening pressure, pleocytosis, hypoglycaemia, hyperproteinorrachia, high lactate, with negative microbiological examination. These clinical data and CSF analysis initially determined acute meningitis. However, the neurological service proposed as a diagnostic impression meningeal carcinomatosis, which required three lumbar punctures to confirm it. Meningeal carcinomatosis is a differential diagnosis that must be considered in a patient with tumoral pathology and meningeal signs. Clinical suspicion, cytochemical findings, and cytology by CSF cyto-centrifuge are important.

Downloads

Download data is not yet available.

References

Baiges-Octavio JJ, Huerta-Villanueva M. Carcinomatosis meníngea. Rev Neurol. 2000; 31:1237-8.

Chamberlain MC. Neoplastic meningitis. Oncologist. 2008; 13(9):967-77.

Milburn-McNulty P, Michael B, Moxham N, Fletcher N, Crooks D. How to do it: how to get the most out of cerebrospinal fluid cytology. Pract Neurol. 2012;12(4):241–3.

Martins SJ, Azevedo CRAS de, Chinen LTD, Cruz MRS, Peterlevitz MA, Gimenes DL. Meningeal carcinomatosis in solid tumors. Arq Neuropsiquiatr. 2011; 69(6):973–80.

Ríos Castillo MC, Moreno MM, Junco MRA, Echavarría ME, Almira SEL, Pérez NFR, et al. Carcinomatosis Leptomeníngea: Presentación de un caso y revisión del tema. Rev. Chil. Neurocirugía. 2013; 39:160-165,

Romero Rojas AE, Mantilla Hernández JC, Melo-Uribe MA, Barajas Solano PA, Chinchilla Olaya SI. Carcinomatosis meníngea como primera manifestación de carcinoma gástrico. Revista Colombiana de Cancerología. 2010; 14(2):110–5.

Guo J-W, Zhang X-T, Chen X-S, Zhang X-C, Zheng G-J, Zhang B-P, et al. Leptomeningeal carcinomatosis as the initial manifestation of gastric adenocarcinoma: a case report. World J Gastroenterol. 2014; 20(8):2120–6.

Clarke JL, Perez HR, Jacks LM, Panageas KS, Deangelis LM. Leptomeningeal metastases in the MRI era. Neurology. 2010; 74(18):1449–54.

Park K-K, Yang S-I, Seo K-W, Kim Y-O, Yoon K-Y. A case of metastatic leptomeningeal carcinomatosis from early gastric carcinoma. World J Surg Oncol. 2012; 10:74.

Wasserstrom WR, Glass J, Posner JB. Diagnosis and treatment of leptomeningeal metastases from solid tumors: experience with 90 patients. Cancer. 1982; 49(4):759-72.

How to Cite
(1)
Zamora Bastidas, T. O.; Bolaños Bravo, H. J.; Cáceres Acosta, M. F.; Linthon, S. A. Meningeal Carcinomatosis. Case Report. Rev. Fac. Cienc. Salud Univ. Cauca 2018, 20, 46-49.
Published
2018-01-01
QR Code